One of the deceased was identified as Shenbagam (60) of MGR Nagar in the city.
A total of 35 people sustained injuries as the milling crowd vied with each other to have a closer look of Mr Karunanidhi.
They were admitted to Rajiv Gandhi Government General Hospital.
Hospital sources said while two people were brought dead with injuries caused in a stampede, 35 people were brought with minor injuries.
Some of the injured suffered from dehydration, as people, braving the intense heat, thronged in large numbers to have a glimpse of the late leader for one last time.
Commotion prevailed for a while as the milling crowd tried to breach police barricades to have a closer look of their leader and police used mild force to regulate them. (UNI)